Deciphering RNA

The RiboClub brings together ribonucleic acid (RNA) biologists aiming at promoting the study of RNA evolution, structure and function. By fostering regular meetings, exchanging ideas, and sharing infrastructure, the RiboClub creates a unique atmosphere for the recruitment and development of young researchers.

The RiboClub 2021 meeting will take place in person condition permits and will automatically convert to partial or full virtual form in case of public-health crisis. Registration will be open by the end of March.

Deciphering RNA

The RiboClub brings together ribonucleic acid (RNA) biologists aiming at promoting the study of RNA evolution, structure and function. By fostering regular meetings, exchanging ideas, and sharing infrastructure, the RiboClub creates a unique atmosphere for the recruitment and development of young researchers.

Latest News

UPCOMING SEMINAR

 
The RiboClub will continue its monthly activity through videoconference
Next Seminar on March 8, 16:30 h ET
 

To connect to the videoconference, you can click HERE

For any question about the videoconference, please see seminars or contact us

2021 RNA Biology Symposium

Hosted by the NCI RNA Biology Initiative

Registration and Abstract Submission Now Open!

(Registration is required in order to receive the WebEx link)

 

Date:  April 14-16, 2021
Location: Virtual
Event Websitehttps://ncifrederick.cancer.gov/events/conferences/2021-rna-biology-symposium

RNA biology has emerged as one of the most influential areas in modern biology and biomedicine. The discovery of new classes of RNAs and their functions in a wide spectrum of biological processes has revolutionized molecular biology and has profound implications for clinical sciences.  Key areas of current research include the elucidation of RNA biogenesis and structure, the identification of functions for various classes of RNAs, establishing the role of RNA in disease and the exploration of RNA-based-and RNA-targeted therapies.

  • RNA Processing
  • RNA Structure and Mechanism
  • Non-Classical RNAs
  • RNA Therapy

SPEAKERS INCLUDE:

  • Diana Baralle, M.D., MBBS, University of Southampton
  • Brenda Bass, Ph.D., University of Utah
  • Clifford Brangwynne, Ph.D., Princeton University
  • Howard Chang, M.D., Ph.D., Stanford University
  • Nadya Dimitrova, Ph.D., Yale University
  • Julie Forman-Kay, Ph.D., University of Toronto
  • Leemor Joshua-Tor, Ph.D., Cold Spring Harbor
  • Joshua Mendell, M.D., Ph.D., University of Texas Southwestern Medical Center
  • Chad Mirkin, Ph.D., Northwestern University
  • Muthia Monoharan, Ph.D., University of Massachusetts
  • Cara Pager, Ph.D., University of Albany-SUNY
  • Venki Ramakrishnan, Ph.D., Cambridge University
  • Pascale Romby, Ph.D., University of Strasbourg
  • Frank Slack, Ph.D., Beth Israel Deaconess Medical Center
  • Holger Start, Ph.D., Max Planck Institute
  • Yukihide Tomari, Ph.D., University of Tokyo
  • Peter Walter, Ph.D., University of California, San Francisco
  • Blake Wiedenheft, Ph.D., Montana State University

The symposium offers the opportunity to learn more about the current status of RNA biology in development and disease, share research, network with leading figures in the field and discuss the use and implications of these advances for clinical applications.

We hope you join us for the 2021 RNA Biology symposium!

Follow us at: #NCIRNABiology2021

Registration is free but is required in order to receive the WebEx link.

For conference-related questions, please contact [email protected] 

Structural Biology Platform

Université de Montréal / Biochimie et médecine moléculaire

Keywords:
Nuclear magnetic resonance, Small angle X-ray scattering, Biomolecular crystallography, Multi-angle light scattering, Biophysics

Description
The Structural Biology Platform in the department of Biochemistry and Molecular Medicine at the Université de Montréal offers access to several state-of-the-art scientific instruments intended to answer structural biological questions for the scientific community.

The Platform is comprised of three high field nuclear magnetic resonance (NMR) spectrometers (500 MHz, 600 MHz with cryo-probe and 700 MHz) controlled with recent NEO consoles from Bruker. A small angle X-rays scattering (SAXS) instrument, with high-throughput robotics is also available. The SAXS can be coupled to a liquid chromatography system for SEC-SAXS applications.

Other instruments for biophysical investigations of bio-molecules complement the platform: a size-exclusion chromatography system coupled to a multi-angle light scattering detector (SEC-MALS), an isothermal titration calorimetry (ITC) instrument as well as several liquid handling robots for rapid bio-molecular crystal preparation and screening. Users have also access to a bio-informatics room with several Linux computers for data analysis.

Dedicated qualified personnel is always available and will teach and support users on the instruments in order to maximize the quality of the data acquired at the Platform. Research consultation and turn-key services are also available upon request.

Contact information:
Normand Cyr
Université de Montréal, Pavillon Roger-Gaudry
514-343-6322
[email protected]
https://biochimie.umontreal.ca/en/scientific-platforms-bmm/structural-biology/  

Available Positions

Research associate and expert in the bioinformatics and statistics of transcriptomics

General Information

Become a member of the U de Sherbrooke RNomics platform (https://rnomics.med.usherbrooke.ca). A dynamic and unique service platform specialized in RNA biology and the detection RNA variants. The platform goal is to support scientists in Sherbrooke, Canadian and international scientists interested in transcriptomics. The platform offers a complete turnkey service that include sample preparation, isolation quality control, sequencing, PCR and primary bioinformatics support and analysis. The platform is an opportunity to develop stable career in research with focus on service and international collaboration.

Job Summary

The applicant will join a team for researchers in the U de S RNomics platform to oversee the experimental design of the sequencing and PCR pipeline,  statistical analysis of data and the maintenance and development of the client’s databases. The RNomics platform is a U de S core facility housed at the faculty of medicine that aims to service the U de Sherbrooke researchers as well as national and international scientists. The successful applicant will form the first contact with the perspective clients to help them design their experiments, design primers, determine number of replicates and overall experimental design. Once the data are generated the successful applicant will evaluate the data and  communicate the results to the clients.

Task and responsibility
  1. Communication with the clients
  2. Design and implements bioinformatics pipelines for RT-qPCR, ddPCR and RNAseq
  3. Generate, establish and maintain communication protocol between sequencing, PCR and robotics infrastructure and analysis data basis
  4. design, implementation, execution, and optimization of genetic data processing workflows
  5. Design and implement algorithms and programs for transcriptomic data analysis
  6. Debug and modify existing algorithms, LIMS, databases and transcriptomics analysis programs
  7. Performing transcriptomics data quality checks and analysis
  8. Communicating results on a regular basis to clients (e.g. e. mai, phone, databases etc)
  9. Represent the platform in meeting, seminar and special events
  10. Assist platform clients in writing statistical and bioinformatics section in grants application and publication
Required Qualification:
  1. D. in computational biology or related field with focus on statistics and transcriptomics
  2. Documented experience in the analysis of transcriptomics and or genomic data sets
  3. Experience in Object-oriented programming in Java, Perl and Pytho
  4. Web development: knowledge of CMS and MVC concepts, frameworks such as Liferay, Perl Catalyst or Django.
  5. Experience in Relational database management (MySQL)
  6. Experience in versioning system such as Git, hosted on Bitbucket
  7. Experience in system administration in a Linux (Ubuntu) environment: SSL security, Apache, Tomcat, shell scripting
Additional preferred skills:
  • Excellent communication skill in English and French is a plus
  • Demonstrate competence in projects planification and administration
  • Multitasking and ability to manage many projects at once
  • Ability to evaluate delays and resources needed to achieve a project, and to suggest possibilities of optimization
  • Ability to work autonomously
  • Basic background in biology with knowledge of PCR and sequencing techniques

To apply visit this site 
https://www.usherbrooke.ca/emplois/offre/no/04516

or Send your cover letter, CV, career statement, names of three references and your contact information to
[email protected]

Application should be received by February 8, 2021

TENURE TRACK FACULTY POSITIONS IN THE DEPARTMENT OF
MICROBIOLOGY AND INFECTIOUS DESEASES

 

The Department of Microbiology and Infectious Diseases of the Faculty of Medicine and Health Sciences atthe Université de Sherbrooke (www.usherbrooke.ca/dep-microbiologie/) invites applications for multiple tenure-track Faculty positions at the rank of assistant and associate professor in viral and microbialRNA biology and transcriptomics. Applications should be received before March 31, 2021 to be considered.Outstanding candidates that meet the criteria for the Canada Research Chair program (https://www.chairs-chaires.gc.ca) may also apply via the Université de Sherbrooke web interface: www.usherbrooke.ca/emplois/offre/no/04424 by February 8, 2021.

We seek RNA biologists with expertise in microbiology, genomics, molecular biology or related field withinterest in the transcriptomics and genomics of microbiome, molecular epidemiology, host-pathogen interactions, RNA viruses, drug resistance and bacterial pathogen. Candidates must hold a PhD and/or MDdegree and at least two years of postdoctoral training with excellent publication record.

The successful candidate will join 10 RNA biologists in Sherbrooke RNA group and 18 clinical and fundamental microbiologists at the department of microbiology. Being located on the health campus, next tothe university hospital and clinical research center, our research environment is ideal to conduct projectsinvolving clinical samples and patients. Our researchers also have access to multiple technological platforms in RNomics, sequencing, digital PCR, mass spectrometry, microscopy and imaging. The Université deSherbrooke has built a critical mass of expertise in RNA biology (small RNAs, telomerase, splicing) and cancer (colorectal, breast and ovarian), leading to the development of a dynamic academic and technicalinfrastructure (e.g. RiboClub, www.riboclub.org, a RNomics platform, https://rnomics.med.usherbrooke.ca, and a Cancer research axis, http://cr.chus.qc.ca/axes/cancer/). Candidates whose research programinvolves pathogens will have access to a state-of-the-art BSL-3 facility to be built in a new research pavilion dedicated to personalized medicine and translational research. The Successful applicant will be givengenerous startup funds and offered a mentoring program to connect them to both local, national andinternational resources. Possibilities of creating collaborations across the faculty and university also exist sinceresearch projects in bacteriology and virology are also conducted in the Department of Biochemistry(www.usherbrooke.ca/dep-biochimie/) and Biology (Faculty of Sciences, www.usherbrooke.ca/biologie/).

The successful candidate is expected to maintain a competitive externally funded research program and participate in undergraduate and graduate teaching. Candidate should have working knowledge of French or commitment to learn French within the first 5 years of their appointment.

The Université de Sherbrooke is a leading francophone institution recognized for the quality of training andinnovation. The University has more than 40 000 students from 97 countries and employs over 6 000 people.The city of Sherbrooke is renowned for its excellent school system, quality of life, and access to exceptionaloutdoor activities. The university of Sherbrooke firmly supports equity, inclusion and diversity and encourageswomen, members of visible minorities, and people with disabilities to apply.

To apply, please send: 1) Your contact details including email address and telephone number, 2) the date ofyour highest or more relevant degree earned and the name of the degree-granting institution, 3) Cover letterand curriculum vitae, 4) A statement of research interests and future plans (2 pages maximum) and 5) Thenames and contact information for three references.

The applications and documents should be sent to the search committee: [email protected]

Post-Doctoral Fellow


Start date:
Immediate (January, 2021)

Qualifications: Experience in RNA biology and associated techniques and a productive graduate and/or undergraduate degree; lab experience in handling and experimentation with viruses in higher level biosecurity containment is a plus, but training will be provided.

Remuneration: As per CIHR and institutional guidelines.

Subject: Liquid-liquid phase separation and implications in the control of viral replication.

The Mouland lab has historically focused on RNA virus replication (retroviruses including HIV-1, and emerging viruses such as Zika and Ebola and others) and how they counter anti-viral stress responses elicited in infected cells. As one of the countermeasures, these viruses disassemble membraneless organelles such as stress granules. However, they also have ways to promote the assembly of specialized, virus-specific membraneless organelles that contribute to RNA positioning to promote virus replication. As a Post-Doctoral Fellow in the lab you will address key hypotheses to explore and solve mechanistic details on how these viruses create a favourable environment for replication by phase separation.

Please refer to this link for latest references:
https://pubmed.ncbi.nlm.nih.gov/?term=Mouland+aj+phase+separation

Contact information: Please send CV and names of two referees to: [email protected]

Postdoctoral position in Biochemistry/Molecular Biology on the study of RNA G-quadruplex (G4) patterns form the neurones (University of Sherbrooke, Canada)

A two-year fellowship is available to work on the characterization of RNA G4 across the transcriptomes of various cell types of the human nervous system. The objectives are to analyse the structure of these G4s, to determine their contribution on the post-transcriptional regulation of the health and disease cells, and to modulate their folding in cells. The research group of Pr. Perreault is at the Department of Biochemistry and Functional Genomics of the Faculty of Medicine and Health Sciences. It has expertise in the prediction and the study of RNA G4 http://jpperreaultlab.recherche.usherbrooke.ca/. For more information or to apply, please send your CV with a short description of your motivation to [email protected]

The University of Sherbrooke is a French-speaking institution that offers the opportunity to benefit from an academic education and a research environment that are recognized and valued around the world. It hosts more than 30 000 students, including more than 1,600 foreign students from 120 countries worldwide. More than 85% of the students enrolled at the University are from outside Sherbrooke. Sherbrooke is a friendly, dynamic, bilingual city. It is the 6th most important city in Québec with about 160 000 citizens, located among hills, valleys and plateaus. Sports, nature and culture lovers will find that Sherbrooke offers them all sorts of activities including hiking, skiing, golfing, biking, as well as art galleries, museums, theatre, fine dining, cinemas and numerous other activities for culture aficionados.

For a more detailed proposal (English and French), please see here

Tools & Services

LabCollector

Lab Data Management for RiboClub associated labs

RiboSubstrates

 Search for siRNA, SOFA-HDV, Hammerhead substrates

RASE

 Primer Design. Real-time PCR Annotation of Splicing Event

G-browse

The Generic Genome Browser

RTAnalizer

Analysis of non-autonomous retrotransposons in sequenced mammals

RNomics

Palace

Structural Biology

Platform
Université de Montréal

biology-220005_960_720

Our Mission Statement

The RiboClub was founded in 1999 by researchers at the Faculty of Medicine and Health Sciences of the Université de Sherbrooke. All the founding members have a particular interest in some aspect of RNA biology.

The RiboClub was put in place in order to :

• Establish an exceptional environment for students.
• Encourage students to interact and exchange with other students within the RiboClub.
• Stimulate interdisciplinary collaborations between groups.
• Foster the initiation of innovative projects that span multiple areas of expertise.
• Offer access to the latest technology infrastructure.
• Organize a monthly seminar series and an annual meeting.

The Université de Sherbrooke recognizes these activities and conferred us the status of “Center of Excellence in RNA Biology”. The actual research activities of the RiboClub members and associated labs include all nuances of the modern RNA field such as RNA expression, maturation (modification, cleavage and trimming, splicing), transport, and structure.

Our Mission Statement

The RiboClub was founded in 1999 by researchers at the faculty of medicine and health sciences of the Université de Sherbrooke. All the founding members have a particular interest in some aspect of RNA biology and the RiboClub was put in place in order to :

• Establish an exceptional environment for students.
• Encourage students to interact and exchange with students in other groups within the RiboClub.
• Stimulate interdisciplinary collaborations between groups.
• Foster the initiation of innovative projects that span multiple areas of expertise.
• Offer access to latest technology infrastructure.
• Organize a monthly seminar series and an annual meeting for an increased information flow.

The Université de Sherbrooke recognizes these activities and conferred us the status of “Center of Excellence in RNA Biology”. The actual research activities of the RiboClub members and associated labs include all nuances of the modern RNA field such as RNA expression, maturation (modification, cleavage and trimming, splicing), transport, the tridimensional structure and the proteins associated with RNA to form RNPs.